International Journal of Medical Investigation
Int J Med Invest
Medical Sciences
http://intjmi.com
1
admin
2322-2913
2345-640x
no
no
14
8888
13
en
jalali
1397
6
1
gregorian
2018
9
1
7
3
online
1
fulltext
en
Ectopic Cushing's syndrome Of Unknown Origin: A Rare Case Report
عمومى
General
گزارش مورد
case report
Background: Cushing’s syndrome is a rare disease caused by excessive secretion of cortisol by adrenal cortex (hypercortisolism). Bilateral adrenal hyperplasia due to increased secretion of adrenocorticotropic hormone (ACTH) by pituitary gland is usually known as the main cause of Cushing’s syndrome. The 5-year survival rate for patient with Cushing’s syndrome is approximately 50% unless associated with treatment. Etiologic diagnosis therefore plays an important role in prompt treatment. The purpose of this study is to inspect a Cushing’s syndrome with unknown cause. Case presentation: A 36-year-old married man with complaint of periorbital and upper trunk swelling (with no buffalo hump) and lower extremity weakness presented to doctor’s clinic. He also had a one-year history of blurred vision, hypertension, facial and periorbital edema and difficulty getting up from a sitting. After physical examinations and laboratory testing, diagnosis of Cushing’s disease with unknown cause was made and surgical removal of both adrenal glands was suggested. He underwent bilateral adrenalectomy in two separate operations and his symptoms gradually reduced during the next months. Conclusion: According to this study and other same case report studies conducted, surgical removal of adrenal gland is the most effective treatment if the patient does not respond to medication. Even if the cause of Cushing’s disease is not known, like the case mentioned.
Cushing's syndrome, Adrenocorticotropic hormone, hypercortisolism
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82
http://intjmi.com/browse.php?a_code=A-10-1-223&slc_lang=en&sid=1
Saied
Amirkhanlou
10031947532846002026
10031947532846002026
No
Department of Internal Medicine, Golestan University of Medical Sciences, Golestan, Iran.
Mohammad Mehdi
Ebrahimi
10031947532846002027
10031947532846002027
No
Department of Internal Medicine, Golestan University of Medical Sciences, Golestan, Iran.
Arash
Rezaei Shahmirzadi
10031947532846002028
10031947532846002028
Yes
Medical student, Student Research Committee, Golestan University of Medical Sciences, Golestan, Iran