The Evaluation of the Effect of Prenatal Copper Supplementation on Pregnancy Outcomes in Pregnant Women with Cupper Deficiency

yazdani, Maryam; Salimi Kordasiabi, Amir Hossein

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Volume 6, Issue 4 (12-2017)

Int J Med Invest 2017, 6(4): 168-175

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The Evaluation of the Effect of Prenatal Copper Supplementation on Pregnancy Outcomes in Pregnant Women with Cupper Deficiency

Maryam Yazdani

, Amir Hossein Salimi Kordasiabi ^*

Medical Doctor, Research & Development Center Hospital Sayyed Shirazi, Golestan University of Medical Sciences, Golestan, Iran

Abstract: (7158 Views)

Introduction: Copper (Cu) is an essential trace element for the body and seems to play an important role in the final outcome of a successful pregnancy. Some studies have shown an increase in serum levels of copper in pathological pregnancies during the first trimester. This study aimed to evaluate the effect of copper supplementation in pregnant women was designed with copper deficiency on pregnancy outcomes. Methods: This double-blind randomized controlled clinical trial on pregnant women with gestational age of 16-12 weeks was conducted during 2014-2015. The copper levels measured in pregnant women, then 120 qualified mothers have serum levels of copper at less than normal baseline values (120 μg / dL) have been selected. Data analysis with statistical software SPSS-21 and chi-square and independent t-test were done. Findings: Of the 120 cases studied, 20 patients (16.6% of the total) had premature rupture of membranes which 6 women were in the case and 14 women were in the control group and statistical tests showed a significant difference between the two groups (P=0.025). Also among the 120 cases studied, 23 patients (19.1% of total) with pre-eclampsia which 8 women were in the case and 15 women were in the control group and statistical tests showed a significant difference between the two groups (P=0.034). Other variables include spontaneous abortion, preterm delivery, placental abruption, low birth weight, intrauterine growth restriction, and intrauterine fetal death there was no significant difference between the two groups. Conclusion: Based on our findings, supplementation containing copper in pregnant women can reduce the risk of pre-eclampsia and premature rupture of the fetal membranes that Both can be serious consequences, such as infection of membranes, miscarriage or intrauterine death or life-threatening for the mother.

Keywords: Pregnancy, Copper serum level, Premature rupture of membranes

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Type of Study: Research | Subject: General

References

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yazdani M, Salimi Kordasiabi A H. The Evaluation of the Effect of Prenatal Copper Supplementation on Pregnancy Outcomes in Pregnant Women with Cupper Deficiency. Int J Med Invest 2017; 6 (4) :168-175
URL: http://intjmi.com/article-1-292-en.html

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