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EFFICACY OF ANTIVIRAL TREATMENT ON HIV + PATIENTS AND CD4 + TCELL
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Seyyed Abbas Hashemi   , Abediankenari Saeid * , Farhang Babamahmood , Mohammad Reza Parsai |
| Microbiology And Immunology Department, Faculty Of Medicine, Mazandaran University Of Medical Sciences, Sari IRAN |
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Abstract: (10059 Views) |
| Background: Acquired immunodeficiency syndrome is an important infectious disease in contamination of committed T cells. There is a global widespread infection of HIV .The end stage of HIV infection is one of the most causes of death across the world. HIV transmission can be introduced by infecting CD4+ cells.
Objective: For understanding the progression of virus and usefulness of treatment, we measured the number of CD4+ cells change.
Materials and Methods: We monitored the count of CD4+ cells by Flowcytometry before and during treatment of HIV infected people by Ziduvudine 100 mg twice a day, Lamivudine 150 mg twice a day and Nevirapin 200 mg a day, retrospectively.
Results: The study population included 195 HIV positive patients, 87.1% men and 12.8% women. Most of infected patients were older than 40 years old (29.2%). CD4 counts of 20 patients were less than 350 and received treatment. Patients with CD4 count less than 350 withdrew antiviral therapy. At first stage of treatment, patients with CD4 count less than 100 were 58.3% of infected patients but after treatment with antiviral drugs for six months it decreased to 33%. CD4 count of 25% of these people changed to more than 350 while before cure we did not have CD4 count more than 350 among these patients.
Conclusion: After six months treatment, 25% of patients CD4 count reached to more than 350 and showed that at early stage of AIDS we can control the disease and therapy can have beneficial effects in some patients. |
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| Keywords: HIV, Ziduvudine, Lamivudine, Nevirapin, CD4 count |
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Full-Text [PDF 532 kb]
(2399 Downloads)
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Type of Study: Research |
Subject:
General
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