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Mycosis Fungoides Skin Wound Management With Skin Graft Post Ultraviolet Radiation therapy
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چکیده: (7637 مشاهده) |
| Objective : To assess the survival rate of skin graft management in skin lesions of mycosis fungoides patients after therapy with ultraviolet radiation. Methods : Between February. 2011 and June 2015, 89 [8- 81 yrs. ] mycosis fungoides patients were followed up at dermatology clinic, the initial investigations were skin biopsy and the most common used therapy is photo therapy with ultraviolet radiation ( according to stage in the histopathologic reports ) Results : Of the 89 patients that we followed , 90% treated with phototherapy (80 patients ), 35% of them ( 28patients ) of these patients were managed by skin grafts of skin lesions and ulcers , 10% of them ( 3patients ) the skin graft didn’t survive without previous therapy with ultraviolet radiation , 90% (25patients ) of them the grafted areas survived after phototherapy of UVA ,UVB radiation to the potential donor site, the other 65% (52patients ) of the followed pts were managed without skin graft for the ulcerated skin lesions , 38% of them healed spontaneously , others didn’t healed for a long time and need skin graft. Conclusion: Mycosis fungoides is the most common type of cutaneous T lymphoma, pts who received phototherapy to the potential donor site has proven beneficial for skin graft survival , since ultraviolet radiation A,B ,decrease the cytotoxic T lymphocyte activity and decrease inflammatory cells in both graft and donor tissues , with decrease in the antigen presenting cells expression, which leads to decrease in the delayed type hyper sensitivity reaction and increase graft uptake. |
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نوع مطالعه: پژوهشي |
موضوع مقاله:
عمومى
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