[Home ] [Archive]    
:: Main About journal Editorial Board Current Issue Archive Submit an article Site Map Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Editorial Board::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 5, Issue 1 (march 2016) ::
Int J Med Invest 2016, 5(1): 28-31 Back to browse issues page
Azithromycin pharmacokinetic attitude attains the basis for single daily dose for uncomplicated skin infections
Shireen Imad Hijazeen * , Rawan Mahmoud Al-dabbas , Alaa Mohammad Al-aqarbeh , Tamara SalehTweissi , Alaa Mohamed Mrayat
Department of pharmacy,Royal medical services,King Hussein medical services Amman,Hashemite kingdom of Jordan
Abstract:   (7971 Views)

Abstract
Objective: Uncomplicated skin infections are considered a frequent clinical issue. Most of them are induced by staphylococcus and streptococcus. Various oral antibiotics are administered with similar efficiency but with different management period, price and side effects. Azithromycin is used in adults conventionally in a dose of 500 mg once for 5 days. To assess if a single oral 2 g administration dose of azithromycin could cause a therapeutical effect similar to traditional single oral dosing of 500 mg daily for 5 days in adults.
Methods: This randomized and prospective investigation included adult subjects, of both gender and presenting with uncomplicated skin infections at King Hussein hospital. King Hussein medical center, Amman, Jordan, during the period Feb 2012-Mar 2015,after obtaining written informed consent from all participants .All patients were divided into two groups. Group I (n = 146) patients received a 2 g single oral dose and group II patients (n = 146) received a traditional oral dose of 500 mg once daily for 5 days. Adherence was related to the number of tablets taken. Complete clinical healing defines complete healing of lesions with no residual signs or symptoms within 7 days. Normal distributed numerical parameters were compared between groups by Student's t-test or by Mann-Whitney U-test, if abnormal distributed. Pearson's Chi-square test was used for intergroup comparison of categorical parameters. Statistical significance was scored if P < 0.05.
Results: Increased healing rate was recorded in 97.97% in group I and in 98.63% in group II, with improvement in symptoms from the start of treatment but without statistical significance difference between the two groups
Conclusion: Single 2 g oral azithromycin dose caused the same outcome as traditional azithromycin dosing in uncomplicated skin infections with similar tolerability and with adherence .

Keywords: Azithromycin, uncomplicated skin infection
Full-Text [PDF 187 kb]   (2117 Downloads)    
Type of Study: case report | Subject: General
References
1. 1.Kupper TS, Fuhlbrigge RC. Immune surveillance in the skin: Mechanisms and clinical consequences. Nat Rev Immunol 2004;4:211-22. 2.Seupaul RA. Cephalexin is as effective as clindamycin for the treatment of uncomplicated soft tissue and skin infections in children. J Pediatr 2011;158:861-2. 3.Dryden MS. Complicated skin and soft tissue infection. J Antimicrob Chemother 2010;65 Suppl 3:iii35-44. 4.Jorup-Rönström C, Britton S, Gavlevik A, Gunnarsson K, Redman AC. The course, costs and complications of oral versus intravenous penicillin therapy of erysipelas. Infection 1984;12:390-4. 5.Hepburn MJ, Dooley DP, Skidmore PJ, Ellis MW, Starnes WF, Hasewinkle WC. Comparison of short-course (5 days) and standard (10 days) treatment for uncomplicated cellulitis. Arch Intern Med 2004;164:1669-74. 6.Peters DH, Friedel HA, McTavish D. Azithromycin. A review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy. Drugs 1992;44:750-99. 7.Anonymous. ZITHROMAX ® package insert. New York: Pfizer Inc.; 2013. 8.Wilson SE. The management of skin and skin structure infections in children, adolescents and adults: A review of empiric antimicrobial therapy. Int J Clin Pract 1998;52:414-7. 9.Schatz BS, Karavokiros KT, Taeubel MA, Itokazu GS. Comparison of cefprozil, cefpodoxime proxetil, loracarbef, cefixime, and ceftibuten. Ann Pharmacother 1996;30:258-68.
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hijazeen S I, Al-dabbas R M, Al-aqarbeh A M, SalehTweissi T, Mrayat A M. Azithromycin pharmacokinetic attitude attains the basis for single daily dose for uncomplicated skin infections. Int J Med Invest 2016; 5 (1) :28-31
URL: http://intjmi.com/article-1-219-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 5, Issue 1 (march 2016) Back to browse issues page
International Journal of Medical Investigation
Persian site map - English site map - Created in 0.05 seconds with 37 queries by YEKTAWEB 4645